Water, energy and food security are deeply interconnected. Each of these sectors depends on and sustains the others. An understanding of the interdependencies of natural resources and their planning, management and consumption is at the heart of the Water, Energy, Food security and Eco-systems (WEFE) Nexus approach. Applying the WEFE Nexus approach enables us to look across sectors, and bring synergies to life to ensure inclusive water, energy, food security for all while respecting the capacities of natural environments. This 3-day seminar calls to the research and science community in the Mediterranean region with the aim to stimulate more WEFE Nexus solutions and project proposals.